An essential cofactor for the MTHFR enzyme itself, riboflavin supports cellular energy production, antioxidant activity, and the metabolism of fats, proteins, and carbohydrates. Without adequate B2, even the best methylation protocol can fall short.†

In its active coenzyme form (pyridoxal-5-phosphate), B6 supports over 100 enzyme reactions in the body—including neurotransmitter synthesis, immune function, and the metabolism of proteins, carbohydrates, and fats. No additional conversion required.†

The pre-activated form of folate that bypasses the MTHFR enzyme entirely, delivering the active methyl group your cells need for DNA synthesis, homocysteine metabolism, hormonal balance, and detoxification. This is the form your genetics require.†

The methylated form of B12 works synergistically with methylfolate to support red blood cell formation, nervous system function, and cellular energy production, without requiring conversion from the less bioavailable cyanocobalamin form.†

Also known as betaine, TMG is a natural methyl donor that supports an alternative methylation pathway, helping regulate homocysteine levels, support liver detoxification, and promote healthy digestion. It provides an additional layer of methylation support when B vitamin pathways need reinforcement.†