Product Benefits

Physician Formulated

PHYSICIAN FORMULATED

3rd Party Tested

3RD PARTY TESTED

AIP Friendly

AIP FRIENDLY

GMP Compliant

GMP COMPLIANT

Gluten-free

GLUTEN-FREE

Non-Dairy

NON-DAIRY

Physician Formulated

PHYSICIAN FORMULATED
3rd Party Tested

3RD PARTY TESTED
AIP Friendly

AIP FRIENDLY
GMP Compliant

GMP COMPLIANT
Gluten-free

GLUTEN-FREE
Non-Dairy

NON-DAIRY

Core Health Benefits

Formulated with Diamine Oxidase (DAO)
Helps Break Down Food-Derived Histamines in the Digestive Tract†
Helps Mediate the Body’s Immune Response to Ingested Histamines†

Why I Made This

“Histazyme works like a charm. Taking Histazyme up to 15 minutes before a meal can help break down ingested dietary histamine, thereby eliminating the histamine buildup and immune response and uncomfortable symptoms associated with it.†”

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Frequently Asked Questions

Will Histazyme help break down histamine in my bloodstream and nervous system?

The enzyme in Histazyme, diamine oxidase (DAO), does not absorb intestinally and therefore does not work systemically. Histazyme helps break down food-derived histamine only. This means that you can take it before meals to help break down histamine in the gut, but it will not exert its histamine digesting effects systemically or throughout the body.† 

Can Histazyme help with IgE or IgG immune response related to food allergies the way an antihistamine can?

Histazyme is not an “antihistamine,” which is a class of drugs regulated by the FDA. The enzyme in Histazyme, DAO, is not absorbed and does not have systemic activity. Because of this, Histazyme does not manage or address antibody-related or IgE-related food allergies. Histazyme is NOT INTENDED FOR AND IS NOT EFFECTIVE for symptoms of immune-related food allergies, such as peanuts, shellfish, etc., or for gluten intolerance due to sensitivity or celiac disease.

Where does the DAO enzyme in Histazyme come from?

The DAO enzyme in Histazyme is a porcine glandular extract. This means that if you are in any way allergic to pork, or avoid pork for spiritual or other reasons, you will want to avoid Histazyme as well. 

Featured Resources

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Fermented Foods To Avoid With Candida Overgrowth
In my many years of treating patients for Candida overgrowth, I saw a surprising number of people who were surprised to learn that eating fermented foods could actually be making their condition worse. That’s probably because a number of Candida treatment plans suggest adding fermented foods to your diet to feed the good bacteria in your gut.
Gluten Free Churros
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Gluten Free Churros

These gluten free churros offer a healthier spin on a beloved treat, allowing you to indulge without gluten or inflammatory ingredients. Made with almond and cassava flour for a crisp, golden exterior and a soft interior, these churros deliver the same texture and flavor as traditional versions. A dusting of cinnamon-coconut sugar adds sweetness without blood sugar spikes. To elevate the experience, pair the churros with a rich churros and chocolate dipping sauce made from vegan dark chocolate, coconut oil, and Double Chocolate Paleo Protein powder for a nutritious boost. Perfect for holidays or parties, these dairy-free delights satisfy cravings while supporting your gut, muscle mass, and overall health!
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Leaky gut occurs when the intestinal lining becomes compromised, allowing toxins and undigested food particles to enter the bloodstream. This potentially leads to inflammation, digestive issues, and autoimmune conditions. Healing leaky gut involves following a comprehensive protocol to remove irritants, restore essential nutrients, reinoculate with probiotics, and repair the gut lining with targeted supplements like Leaky Gut Revive® and collagen. Learn more about the signs leaky gut is healing.
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Healthy Living
Nutrition
Are Sugar Alcohols Bad For You?
Sugar alcohols, such as erythritol, xylitol, sorbitol, and maltitol, are low-calorie sweeteners often found in packaged foods. While they can support low-carb diets and dental health, they are heavily processed and may cause digestive issues like bloating, gas, and diarrhea. If you suffer from conditions like Candida overgrowth, leaky gut, or SIBO, sugar alcohols can worsen symptoms by feeding harmful bacteria. Though they are a lower-calorie alternative to sugar, they can still impact blood sugar levels and gut health. To repair gut damage caused by sugar alcohols, consider following a gut-healing protocol like the 4R approach with tools such as Gut ImmunIG™.

†These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

The reviews posted on this site are solely the opinions of our customers and do not represent the views or opinions of AMMD. We do not control, edit, or alter the content of customer-submitted reviews.

4.6
Rated 4.6 out of 5 stars
Based on 214 reviews
Total 5 star reviews: 170 Total 4 star reviews: 25 Total 3 star reviews: 9 Total 2 star reviews: 2 Total 1 star reviews: 8
89%would recommend this product
Reviews Summary
Customers say this supplement helps them enjoy a wider variety of foods with fewer reactions. Many reviews mention improved dining experiences, with users able to eat previously problematic items. While most report positive results, some note experiencing adverse reactions. Common feedback includes its effectiveness for dietary flexibility, though several mention the high price point. Users appreciate the small, easy-to-swallow pills and report varying levels of relief. Some indicate taking it before meals works best, while others use it daily. A few reviews note no noticeable effects, but most describe positive experiences with regular use.
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214 reviews
  • LM
    Linda M.
    Verified Buyer
    21 seconds ago
    Rated 5 out of 5 stars
    Amazing!

    I’ve been suffering for years from what I was told was IBS. I followed the low FODMAP diet but it became increasingly difficult to find foods that didn’t upset my stomach. When I saw an email from you about histamine intolerance I immediately started doing some research and concluded that Histazyme was worth a try. From the first pill I took my stomach felt better. I’ve been able to eat so many more foods! I love this stuff!

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  • CT
    Concetta T. P.
    Verified Buyer
    1 month ago
    Rated 5 out of 5 stars
    Good product

    I have serious histamine issue due to food intolerance and insensitivies. This is working......

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  • TK
    Terri K.
    Verified Buyer
    1 month ago
    Rated 5 out of 5 stars
    DAO for histimine relief

    I have issues with histimine sontake this product to break down it. It works like a charm.

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  • AL
    Annemarie L.
    Verified Buyer
    1 month ago
    Rated 5 out of 5 stars
    Histazyme has been a game changer for me

    While I’m actively working with my doctor to address the root causes of my histamine intolerance, this supplement has made a big difference in my day-to-day life. It’s allowing me to eat foods that aren’t typically part of a low-histamine diet without triggering flare-ups. The improvement has been noticeable and meaningful, and it’s helped me feel more normal and less restricted. I’m really grateful to have found something that supports me so well during this healing process.

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  • LJ
    Lena J.
    Verified Buyer
    1 month ago
    Rated 5 out of 5 stars
    Skin flare-ups gone

    Crediting this supplement with the immediate change and near total reduction of inflammation or flare ups of the skin on my forehead. I am an adult who just developed excema flares in the last 12-16 months- directly related to what I was ingesting, with allergy/intolerance panels indicating nothing. A year between GCP and Gastro revealed nothing- a mystery! AM supplements are providing results, less than 1 month.

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