You’ve made some big changes to improve your health—exercising more, prioritizing sleep, or cleaning up your diet. Maybe you’ve ditched gluten, cut out caffeine and alcohol, and sworn off refined sugar. But instead of feeling amazing, you’re suddenly dealing with headaches, brain fog, nausea, or flu-like aches. What gives? You might be experiencing die off symptoms. It’s a reaction that happens when harmful microbes die off and release toxins faster than your body can eliminate them.
Die-off, a form of a Herxheimer reaction, is a bodily process triggered by a sudden increase in endotoxins. It’s also fairly common when you first start avoiding certain foods such as carbs, sugar, dairy, and alcohol.
Die-off can cause irritability, fatigue, digestive issues, and other unpleasant symptoms that make sticking with beneficial lifestyle changes challenging to say the least. The good news is these symptoms are temporary. They’re a sign you’re on the right track!
To help you avoid die-off — or to quickly remedy it — I have tried-and-true solutions. First, let’s discuss what die-off is and why it happens.
What is Die-off?
When microorganisms in the body such as fungi, yeasts, and bacteria are destroyed, they rapidly release harmful substances called endotoxins into your bloodstream. Your immune system responds to this sudden flood of endotoxins by triggering an acute immune response. As a result, inflammation can be experienced throughout the body. This can lead to worsening die off symptoms and the development of new ones.
Die-off or Herxheimer reaction is commonly the result of medications such as antifungals or antibiotics. (1) However, what many people don’t realize is that die-off and die off symptoms can also occur when they suddenly change their diets during a detox or cleanse — or switch to a healthy eating plan.
The Herxheimer Reaction
Die-off is also known as the Herxheimer Reaction or Jarisch-Herxheimer Reaction (JHR). Despite how it may feel, it’s actually a sign you’re going in the right direction.
JHR was first described by Austrian dermatologist Adolf Jarisch in the late 1800s when he noticed an increase in skin lesions in a patient after starting antibiotic treatment for syphilis. In the early 1900s, a similar reaction was reported by German dermatologist Karl Herxheimer.
The Jarish-Herxheimer reaction often goes untreated. This is because symptoms such as fever, chills, body aches, and skin rash are often present before treatment.
As a result, worsening symptoms after treatment are simply overlooked as signs of the underlying infection. More commonly, however, the Herxheimer reaction is often mistaken for an antibiotic allergy.
As I mentioned above, the Herxheimer reaction occurs when microorganisms such as fungi and yeast are destroyed. This means your treatment, diet, or detox is working.
Nevertheless, an increase in toxins is never a good thing. All those endotoxins released by dying microorganisms can strain your detoxing organs as they attempt to bind and flush them out of your system. Plus, the longer toxins remain in your body, your chances of reabsorbing them increase drastically.
What Causes Die-Off?
Treatment of viruses, bacteria, and fungi, whether by taking antibiotics or starting a low-carb diet, can trigger a Herxheimer reaction. Die off symptoms typically appear within six to eight hours after beginning treatment. They resolve as you continue dieting or taking your prescribed medication.
Die-Off in Action
The bacteria and yeasts that live in your gut thrive on sugar. A small amount of these bacteria and yeasts, including Candida, are critical for digestion. They’re beneficial to your gut health.
However, if you’ve been consuming a diet high in carbs, sugar, and alcohol, you likely have many more of these microorganisms than your body needs. Through complex chemical processes, these microorganisms fuel your desire to consume even more carbs and sugars. So, when you limit your intake of sugar and carbs, it starves this overpopulation, causing a Herxheimer reaction.
As yeasts die, they release a toxic substance called acetaldehyde. This is the same byproduct produced when you drink alcohol. Acetaldehyde is a neurotoxin that can be irritating to your brain and cause neurologic symptoms.
Consequently, some people feel drunk while experiencing die-off. To make matters worse, yeast also produces a toxin known as gliotoxin. This can suppress your immune system and damage your liver cells. (2) Because your body is being flooded with toxins faster than it can clear them, you can experience a range of issues that typically last 3-7 days. (3)
Die off Symptoms
Because there is an increase in toxins circulating in your bloodstream during a Herxheimer reaction, your immune system jumps into action by entering into a state of inflammation. This results in a range of die off symptoms that vary in duration and severity.
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Headaches
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Fatigue
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Bloating
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Diarrhea or constipation
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Joint pain
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Nausea
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Flu-like symptoms
You’re more likely to experience die off symptoms if your detox pathways are compromised (e.g., if you have an MTHFR mutation). You could also experience symptoms if you already have a high toxic burden and the dying microorganisms are overwhelming your system. It could also be that you’ve been clearing an overgrowth of pathogenic or opportunistic microorganisms too quickly.
Candida Die-Off
Candida die-off results from treatments that combat an overgrowth of Candida yeast cells. (4) When your body overproduces Candida, it breaks down the walls of the intestine and penetrates the bloodstream. This releases toxic byproducts into your body and causes leaky gut. Candida die off symptoms can come on suddenly and range in severity. (5)
Candida Die Off Symptoms
The most common Candida die off symptom is a low-grade fever. Fluctuation in body temperature is often accompanied by other Candida die off symptoms such as nausea, headache, or chills. In the flare stage, a Herxheimer reaction causes an aggravation of Candida die off symptoms as your body attempts to flush the excess endotoxins from your body.
You might notice Candida die off symptoms beginning within a few hours of your first treatment and resolving within 24 hours. However, this can vary depending on the severity of your Candida overgrowth. During this time, you might experience Candida die off symptoms such as:
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Fever
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Chills
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Skin rash
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Mild decrease in blood pressure
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Muscle aches
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Weakness
Minimize Candida Die-off & Fight Candida Overgrowth
You can take on Candida today by following the 30-day Candida Support Protocol. By following this simple and proven three-action approach, you can effectively support yeast balance in your digestive tract.
This method includes powerful nutritional supplements to discourage opportunistic yeast growth. In addition, it has an easy-to-follow anti-Candida diet meal plan packed with foods that help eliminate Candida. Using this approach, you’ll:
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Starve the Candida by removing foods that feed it from your diet. This means eliminating all sugar and alcohol and restricting carbohydrates such as fruit, starchy vegetables, grains, and legumes. It also means ditching all fermented foods.
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Attack the Candida by taking supplements that destroy Candida’s cell walls. The Candida Support Protocol includes Candifense® and Caprylic Acid, both of which are excellent at breaking down the walls of Candida cells to destroy them.
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Candifense® is an enzyme-based formula capable of breaking down cellulose, which makes up the cell wall of many opportunistic yeasts, including Candida albicans. It’s a safe, effective, and gentle approach to maintaining a healthy microflora balance throughout the digestive tract.
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Caprylic Acid is a great way to support yeast balance throughout the body. This short-chain fatty acid creates an inhospitable environment for opportunistic yeast, especially in cases of Candida overgrowth.
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Repopulate your good bacteria by taking a high-potency probiotic that controls Candida. While battling Candida, I recommend a probiotic supplement containing 100 billion colony-forming units (CFUs) to restore your gut’s healthy microbial balance.
The Candida Support Protocol contains my Probiotic Capsules 100 Billion. It’s a potent, fourteen-strain probiotic for maximum digestive health and immune support that is excellent at crowding out Candida yeast. It also produces beneficial lactic acid in the gut, which Candida overgrowth hates!
SIBO Die-Off
Small Intestinal Bacterial Overgrowth, or SIBO, occurs when the bacteria in your small intestine become unbalanced and overgrow. Most of your gut bacteria are meant to be located in your large intestine and colon, where they help break down food, synthesize vitamins, and eliminate waste.
However, when bacteria normally found in the large intestine and colon begin to colonize in the small intestine, bacterial overgrowth occurs. Small intestinal bacterial overgrowth can also occur when there is an overgrowth of otherwise normal bacteria in the small intestine.
After you begin treatment and the overgrown microbiota begins to die, your immune system kicks into high gear to combat the increased endotoxins being released into your system. As a result, this causes a wide range of SIBO die-off symptoms.
SIBO Die-Off Symptoms
As the dying microorganisms fight to stay alive in your gut, you might experience SIBO die-off symptoms such as:
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Chills
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Fatigue
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Headache
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Muscle aches
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Brain fog
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Worsening of SIBO symptoms (bloating, constipation, diarrhea, etc.)
You may experience only one of these SIBO die-off symptoms, or you may even experience all possible SIBO die-off symptoms at once.
H Pylori Die Off Symptoms
Helicobacter pylori (H pylori) is a type of bacterial overgrowth that causes chronic inflammation in the gut and is a common cause of ulcers worldwide. H. pylori causes inflammation by invading your stomach lining and producing a cytotoxin called vacuolating cytotoxin A (Vac-A), which can lead to ulcer formation. Because H. pylori infection disrupts the delicate balance of bacteria in your gut, it may be a precursor to developing full-blown SIBO. H. pylori die-off symptoms include:
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Digestive issues such as bloating, gas, nausea, and vomiting
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Fatigue
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Decreased appetite
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Heartburn
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Low red blood cell count (anemia)
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Peptic ulcers
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Bad breath
Minimize SIBO Die Off Symptoms
Treating your SIBO is a 3-step approach that works to eliminate the overgrowth and restore your gut’s natural balance. My SIBO Support Protocol is a step-by-step process to help you beat small intestinal bacterial overgrowth for good.
In it, you’ll find all the information you need to get control over the overgrowth. With the SIBO Support Protocol, not only do you get information, supplements, and a solution,but you also get the support you need to take on these three steps:
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Starve the overgrown bacteria by removing foods that feed it from your diet. This means no sugar and alcohol and limiting inflammatory foods such as starchy vegetables, carbohydrates, grains, and legumes.
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Attack the bacteria. The SIBO Support Protocol includes Microb-Clear®. It’s a potent combination of herbs and beneficial fatty acids to prune back the overgrown bacteria that don’t belong in your small intestine.
Moreover, the cutting-edge botanical extracts in Microb-Clear® support optimal bacterial balance. They also play a beneficial role in supporting optimal yeast and parasite balance.
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Restore the good bacteria in your gut. The SIBO Support Protocol includes three powerful supplements to support a strong immune system, optimal digestion, and nutrient absorption.
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Primal Earth Probiotic™ contains three highly researched strains of bacteria that don’t feed the SIBO fire. Instead they’re delivered in a seed-like protective barrier so they arrive intact in your large intestine and colon.
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Coconut Charcoal is activated charcoal derived from coconut shells to absorb the toxic byproducts released by the dying bacteria. This eases die-off symptoms.
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The Myers Way® Vanilla Bean Paleo Protein is gluten-, dairy-, and sugar-free so you can quickly and easily prepare the delicious smoothies included in the 30-day meal plan. It’s delicious!
Parasite Die-Off
A parasite is any organism that lives and feeds off of another organism. Usually, intestinal parasites are parasitic worms that feed off the material in your body. As horrifying as that sounds, they’re surprisingly common. Some examples include tapeworms, roundworms, pinworms, whipworms, and hookworms.
Parasites can release neurotoxins, heavy metals, viruses, and other toxins when they die. The result? You could experience a wide range of unpleasant parasite die-off symptoms.
What’s more, if you have an autoimmune disease and your body is unable to detox, those toxins are left to recirculate as they wait to be detoxified. This can make parasite die-off symptoms even worse! (6)
Parasite Die-Off Symptoms
Parasites typically have life cycles that can last between 7-21 days. Consequently, parasite die-off symptoms can flare during certain phases of these life cycles. During a flare, parasite die-off symptoms include:
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Fatigue
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Headache
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Skin rashes
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Teeth grinding
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Weight loss
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Flu-like symptoms
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Insomnia
These parasite die-off symptoms can be as unpleasant as the living period of a parasite — or even worse! If you’re experiencing parasite die-off symptoms, it’s important to take care of your health as soon as possible.
How to Avoid Die-off
When you have an overgrowth of bacteria, whether it be Candida overgrowth or SIBO, it can break down the walls of your intestines. As a result, it can cause leaky gut. Now, the bacteria can travel throughout your body.
From there, it can colonize your skin, ears, thyroid, respiratory tract, and other areas of your body. This can lead to symptoms including brain fog, skin irritation, seasonal allergies, mood swings, and autoimmune disorders. Even more, if you’re dealing with a parasite, these symptoms increase greatly as your detoxing organs become compromised.
So, if a Herxheimer reaction is an indication that you are clearing an overgrowth of bacteria and yeast from your body, why would you want to avoid it?
Aside from feeling miserable, die-off is a toxic state. The longer your body remains in this toxic state, the more likely you are to reabsorb the toxins being released by the dying microorganisms.
So, let’s take a look at some of the ways you can prevent Candida, parasite, or SIBO die-off symptoms while you transition to a healthy diet. Then, if you’re already experiencing die-off, I’ll cover the steps on how to reduce your symptoms so you can start feeling great again!
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Go Slow
First, it’s important for you to be gentle on yourself. I don’t believe that you need to feel bad in order to feel good. When you clear an overgrowth of microorganisms too quickly, your body simply cannot handle the huge toxic burden from the acetaldehyde being produced.
Take it slow! Begin by gradually transitioning to a diet of less sugar and fewer carbs each day to lessen your die-off symptoms. I also recommend supporting your body with a combination of supplements that naturally support a healthy balance of yeast in your digestive tract and encourage beneficial bacterial growth.
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Reduce Your Toxic Burden
One reason you may experience die-off is that you already have a high accumulation of toxins in your body. Taming the toxins is crucial to help you avoid die-off symptoms. Review Pillar III of The Autoimmune Solution for tips on reducing your toxic burden.
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Support Your Detox Pathways
Remember what I said about gliotoxin damaging your liver cells? Your liver is your primary detox organ. If your liver is not working optimally, it could be why you’ve been dealing with excess yeast in the form of Candida in your gut.
This is why it’s so essential to support your detox pathways.
One of my favorite tools for supporting detox pathways is Acetyl-Glutathione. Glutathione is your body’s most powerful detoxifier, and can help your body process and eliminate toxins. As a bonus, glutathione supports your immune system.
Supplementing with glutathione will help your body counteract the immunosuppressive effects of gliotoxin. This way, you’ll be better equipped to deal with die-off!
Steps to Reduce Die off Symptoms
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Take Coconut Charcoal
Coconut Charcoal binds to toxins and helps flush them from your body safely and quickly. Coconut Charcoal is activated, which means that it’s been heated to extremely high temperatures in order to create millions of tiny little pores, giving it an incredibly large surface area that allows it to bind the toxins, contributing to die-off.
The way that charcoal works is through adsorption rather than absorption. It’s full of negatively charged ions that work like magnets to attract positively charged elements, such as the toxic byproducts released during die-off.
These byproducts bind to the outside of the activated charcoal and get trapped in its tiny little pores. Once trapped, the charcoal effectively carries these harmful byproducts out of your body so they don’t get reabsorbed.
I recommend taking one capsule of Coconut Charcoal in the morning and one capsule in the evening to help minimize die-off symptoms.
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Drink Plenty of Water
You want to make sure you’re drinking at least 8 oz. of filtered water while you’re taking Coconut Charcoal to support your digestion. This is because charcoal may cause constipation. In fact, drinking water is vital during the detox process as it is.
My motto is when it comes to detoxifying, you need to make sure you’re peeing, pooping, and sweating every single day! Drinking plenty of water will help ensure that you’re doing all three of these.
Stirring a scoop of Organic Greens into your water is a simple and effective way to supercharge your detox efforts with immune-boosting greens and superfoods. Organic Greens also spirulina and chlorella, which are natural chelators that can help speed up the elimination of toxins from your body.
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Sweat
When it comes to sweating, my favorite way to sweat out toxins is to get in my infrared sauna. I suggest you learn more about infrared saunas, how they work, and why they benefit your health. I personally use mine a few times a week. It’s a great way to sweat out toxins!
Not everyone has room for an infrared sauna in their house, and that’s ok. You can always do light exercise or use a traditional sauna at your local gym to help you sweat out the toxins.
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Prioritize Sleep
Sleep is critical while you are working to overcome die-off. It’s when your detox pathways are the most active! I recommend getting 8-9 hours of sleep while you are detoxing so that your body has plenty of time to rest and rejuvenate.
Again, if you’re not experiencing die-off, bravo! And if you are having any die-off symptoms whatsoever, fear not — following these simple steps will get you back on track in no time at all.
I am so proud of you for taking your health into your own hands, and remember: you don’t have to go through this alone! If you’re looking for some additional encouragement to achieve your optimal health, check out The Myers Way® Community on Facebook!
The Final Word on What Are Die Off Symptoms & How To Reduce It
Die off symptoms can be uncomfortable — but they’re a sign your body is clearing out harmful microorganisms and toxins. By taking things slow, supporting your detox pathways, staying hydrated, and nourishing your body with the right supplements — such as Coconut Charcoal and Microb-Clear®, you can minimize discomfort and stay on track with your health goals.
Remember — this phase is temporary! Don’t get discouraged by the discomfort. Soon, you’ll feel better, with more energy and a stronger gut. Your body knows what it’s doing. If you need extra support, don’t hesitate to connect with a community or seek guidance. You’re not in this alone—your health journey is worth it!
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